Researchers at DICAT have collaborated with 8 hospitals in USA, Japan, China, and Canada, and several pharmaceutical companies to study human microbiota in hepatocellular carcinoma. The primary goal is to identify certain gut bacteria that can be used to treat liver cancer as a novel therapy.
Glaucoma is the most common cause of age-related blindness in the United States. There is currently no cure, and once vision is lost, the condition is irreversible. Williams et al. now report that vitamin B3 prevents eye degeneration in glaucoma-prone mice. Thus, healthy intake of vitamin B3 may protect eyesight.
Although some animals easily regenerate limbs and heal broken flesh, mammals are generally not so gifted. Wounding can leave scars, which are characterized by a lack of hair follicles and cutaneous fat. Plikus et al. now show that hair follicles in both mice and humans can convert myofibroblasts, the predominant dermal cell in a wound, into adipocytes.
Researchers at DICAT have found that increased autoimmunity risk in glycogen storage disease type 1b is associated with a reduced engagement of glycolysis in t cells and an impaired regulatory T cell function.
Researchers at DICAT have found that selective oral rock2 inhibitor reduces clinical scores in patients with psoriasis vulgaris and normalizes skin pathology via concurrent regulation of IL-17 and IL-10.
Researchers at DICAT have found that Fetal/placental type i ifn can affect maternal survival and fetal viral load during viral infection.
Researchers at DICAT have found that the transcription factor sox2 regulates AID expression in class-switched B cells.
Researchers at DICAT have found that loss of twist1 in the mesenchymal compartment promotes increased fibrosis in experimental lung injury by enhanced expression of cxcl12.
Researchers at DICAT have found that mast cells limit the exacerbation of chronic allergic contact dermatitis in response to repeated allergen exposure.
Researchers at DICAT have found that ERAAP shapes the peptidome associated with classical and nonclassical MHC class I molecules.
Researchers at DICAT have found that lymphocryptovirus infection of nonhuman primate b cells converts destructive into productive processing of the pathogenic cd8 t cell epitope in myelin oligodendrocyte glycoprotein.
Researchers at DICAT have found that fatty acid amide hydrolase regulates peripheral b cell receptor revision, polyreactivity, and b1 cells in lupus.
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